Tag: idiopathic nephrotic syndrome

November 5, 2019

Idiopathic nephrotic syndrome in children

The incidence of idiopathic nephrotic syndrome (NS) is 1¬∑15-16¬∑9 per 100‚Äą000 children, varying by ethnicity and region. The cause remains unknown but the pathogenesis of idiopathic NS is thought to involve immune dysregulation, systemic circulating factors, or inherited structural abnormalities of the podocyte. Genetic risk is more commonly described among children with steroid-resistant disease. The

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November 5, 2019

Management of steroid-resistant nephrotic syndrome in children and adolescents

More than 85% of children and adolescents (majority between 1-12 years old) with idiopathic nephrotic syndrome show complete remission of proteinuria following daily treatment with corticosteroids. Patients who do not show remission after 4 weeks’ treatment with daily prednisolone are considered to have steroid-resistant nephrotic syndrome (SRNS). Renal histology in most patients shows presence of

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