Category: Nephrotic syndrome
Steroid sensitive nephrotic syndrome is one of the most common pediatric glomerular diseases. Unfortunately, it follows a relapsing and remitting course in the majority of cases, with 50% of all cases relapsing once or even more often. Most children with idiopathicnephrotic syndrome respond initially to steroid therapy, nevertheless repeated courses for patients with relapses induce
Nephrotic syndrome is characterized by edema, proteinuria, hypoalbuminemia, and hyperlipidemia. Minimal change disease, the most common cause in childhood, generally responds to corticosteroids, although most patients experience disease relapses. Focal segmental glomerulosclerosis is usually resistant to corticosteroids and carries a significant risk of kidney failure, necessitating renal transplantation. Nephrotic syndrome may also be secondary to
There is a paucity of information on epidemiology, diagnosis, and treatment outcomes of congenital nephrotic syndrome (CNS) in developing countries. This largest reported series on CNS from India revealed suboptimal management with poor outcome as well as low number of CNS being subjected to genetic evaluation. Sources: https://www.ncbi.nlm.nih.gov/pubmed/31655822
Nephrotic syndrome explained: Nephrotic syndrome is a condition which affects the kidneys and the miniscule filtering system within it, called the nephrons. There is damage to these structures as a result of various reasons, and mostly in children the cause remains unknown, also known as idiopathic nephrotic syndrome. As a result of this damage, the
Nephrotic syndrome is a disease of the kidneys which occurs in childhood. It is often called nephrosis or minimal change disease, and is a disease which is characterized by increased leakage of proteins from the body in the urine. This results in increased levels of protein present in the urine and low levels of protein
Current issue of CJASN has an excellent review on Nephrotic syndrome written by Dr Emma and his team. It’s a must read for all pediatricians and fellows in nephrology! Minimal change disease (MCD) is a major cause of idiopathic nephrotic syndrome (NS), characterized by intense proteinuria leading to edema and intravascular volume depletion. Image Source
Today, our colleagues from PGIMER Chandigarh publish in Kidney International, an excellent clinical sign- Melanonychia following cyclophosphamide therapy.